Bariatric surgery is a well-documented treatment for obesity that leads to considerable weight loss and health improvement, but is the surgery successful in the long run in reducing costs associated with medical care for obesity? A team of researchers from the Johns Hopkins Bloomberg School of Public Health and School of Medicine recently undertook a multi-year analysis of health insurance claims data to examine this question and found that although the procedure’s success rate is well documented, it does not have a similar impact on health care costs. The findings were released in the February 20 online edition of the journal JAMA-Surgery.

“The results of our study are important because they demonstrate bariatric surgery does not lower overall health care costs in the long term and we found is no evidence that any one type of surgery is more likely to reduce long-term health care costs,” said Jonathan Weiner, DrPH, professor of Health Policy and Management at the Bloomberg School and lead author of the study. He added, “Future studies should focus on the potential benefit of improved health and well-being of patients undergoing the procedure rather than on cost savings.” Continue reading


I recently underwent a workup for fatigue, which included a sleep study.  Since I had some periodic limb movement (PLM), the doctor decided to draw some blood and run some tests.

One of the tests was called “TSAT,” which is a short name for transferrin saturation.  TSAT tells the doctor how much iron is in your blood.  Too little or too much iron can cause problems.

In my case, there was too little iron.  This is not the first time I’ve heard that.  In fact, my bone marrow biopsy reports usually indicate absent iron storage. Continue reading


Research Shows Fewer Donor Cells May Be Needed for Transplantation and Bone Marrow Banking May Be Possible

NEW YORK (March 21, 2013) — More than 50,000 stem cell transplants are performed each year worldwide. A research team led by Weill Cornell Medical College investigators may have solved a major issue of expanding adult hematopoietic stem cells (HSCs) outside the human body for clinical use in bone marrow transplantation — a critical step towards producing a large supply of blood stem cells needed to restore a healthy blood system.

In the journal Blood, Weill Cornell researchers and collaborators from Memorial-Sloan Kettering Cancer Center describe how they engineered a protein to amplify adult HSCs once they were extracted from the bone marrow of a donor. The engineered protein maintains the expanded HSCs in a stem-like state — meaning, they will not differentiate into specialized blood cell types before they are transplanted in the recipient’s bone marrow.

Finding a bone marrow donor match is challenging and the number of bone marrow cells from a single harvest procedure are often not sufficient for a transplant. Additional rounds of bone marrow harvest and clinical applications to mobilize blood stem cells are often required. Continue reading


Cancer Biologists Find DNA-Damaging Toxins in Common Plant-Based Foods

Release Date: 03/28/2013
Liquid smoke, black and green teas and coffee produced levels of cell DNA damage comparable to chemo drugs

In a laboratory study pairing food chemistry and cancer biology, scientists at the Johns Hopkins Kimmel Cancer Center tested the potentially harmful effect of foods and flavorings on the DNA of cells. They found that liquid smoke flavoring, black and green teas and coffee activated the highest levels of a well-known cancer-linked gene called p53.

The p53 gene becomes activated when DNA is damaged. Its gene product makes repair proteins that mend DNA.  The higher the level of DNA damage, the more p53 becomes activated. Continue reading